Stabilization of Live Mycoplasma gallisepticum Vaccines During Vaccination with Second-Generation Spray-Vac Vaccine Stabilizer

Abstract

ABSTRACT Dilution and application of live Mycoplasma gallisepticum vaccines without the use of vaccine-stabilizing compounds may lead to significant loss of vaccine viability and loss of vaccine efficacy. Vaccine viability may decrease because of osmotic lysis of the mycoplasma as well as the presence of free chlorine or other detrimental chemicals in the water. Second-generation Spray-Vac vaccine stabilizer was developed and shown to maintain live Mycoplasma gallisepticum vaccine viability during exposure to free chlorine while protecting from the other factors that appear to decrease vaccine survival in solution. Increased vaccine survival in solution should lead to increased survival of the vaccine during vaccination. Field trial results demonstrate that second-generation Spray-Vac vaccine stabilizer yields excellent results without the need for distilled water or other vaccine-stabilizing compounds.