Abstract
Sulfite and bisulfite ions are known to attack the optically active side chain of epinephrine in the absence of oxygen by an SN2 mechanism. Evidence is presented whereby chelation of the catechol nucleus with boric acid results in marked stabilization of epinephrine from this type of degradation. The effects of variation of the boric acid and hydrogen ion concentration are investigated. The equilibrium reaction of boric acid and epinephrine are reported in detail and the stability constant for the chelate is evaluated.
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