Abstract
The primary and secondary hydroxyl groups on the β-cyclodextrin molecule were selectively substituted by 2-hydroxypropyl ether groups. The influence of 2-hydroxypropyl-β-cyclodextrin, substituted mainly at the primary or the secondary hydroxyl groups, on the hydrolysis rate of aspartame was investigated and compared to the effects of 2-hydroxypropyl-β-cyclodextrin (Encapsin TM ) from Janssen, a mixture of maltosyl- and dimaltosyl-β-cyclodextrin, and 2-hydroxyethyl-β-cyclodextrin. All the cyclodextrin derivatives decreased the rate of hydrolysis of aspartame in aqueous solution. The distribution of the 2-hydroxypropyl substituent on the β-cyclodextrin molecule affected its stabilizing effect.
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