Abstract
A simple, rapid, precise, rapid, sensitive and reproducible reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed for quantitative analysis of Telmisartan (TELM) in pharmaceutical dosage forms. Chromatographic separation of TELM and its degradation products was achieved on a C18, 250 × 4.6 mm, 5μ, Waters symmetry column.
Highlights
Telmisartan (TELM) chemically described as 4[(1,4‐dimethyl‐2‐propyl(2,6‐bi‐1H‐ benzimidazol]‐1‐yl)methyl][1,1‐biphenyl]‐2‐ carboxylic acid (Figurers 1) is a potent, long‐lasting, nonpeptide antagonist of the angiotensin II (AT1) receptor that is indicated for the treatment of essential hypertension
The majority of methods reported are liquid chromatography coupled to UV, tendem mass spectrometry or mass spectrometry detection but some determinations were performed by thin layer, ratio derivative spectrophotometry and spectrofluorimetry
None of these analytical procedures has been described as a stability-indicating method for analysis of TELM in the presence of its degradation products
Summary
Telmisartan (TELM) chemically described as 4[(1,4‐dimethyl‐2‐propyl(2,6‐bi‐1H‐ benzimidazol]‐1‐yl)methyl][1,1‐biphenyl]‐2‐ carboxylic acid (Figurers 1) is a potent, long‐lasting, nonpeptide antagonist of the angiotensin II (AT1) receptor that is indicated for the treatment of essential hypertension. None of these analytical procedures has been described as a stability-indicating method for analysis of TELM in the presence of its degradation products. Preparation of working standard: From the standard stock solution 10.0 mL is pipette out into 100.0 mL volumetric flask and made up the volume with mobile phase, having the concentration of 10.0 μg/mL of TELM.
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