Abstract
Diabetes mellitus (DM) is one of metabolic syndromes that is characterized by the excessive accumulation of blood glucose, also called as hyperglycemia, and carbohydrate, fat, and protein metabolism disorder. The antioxidant compounds on Ipomoea reptans possesses the pharmacological activity on DM with low absorption in systemic circulation. The absorption and penetration properties of the extract can be improved by making it into the SNEDDS (Self-Nanoemulsifying Drug Delivery) dosage form. Stability is one of the factors that affect the safety, quality and efficacy of the SNEDDS dosage form. This study aimed to evaluate the stability of Ipomoea reptans extract (IpE) SNEDDS. The IpE SNEDDS was made using myritol as the oil phase, tween 20 as surfactants, and polyethylene glycol (PEG) 400 as the cosurfactant. The stability study was conducted with several physical stability tests, which were centrifugation test, heating-cooling cycle test, and freeze-thaw cylcle test. The result indicated that the particle size of the IpE SNEDDS was ≤ 200nm and indicated good physical stability. It can be concluded that the IpE SNEDDS possesses good stability profile.
Highlights
Diabetes mellitus as the third most deadly health problem in the world can lead to complications that worsen the body organs condition such as chronic hyperglycemia, long-term damages, dysfunctions, and organ failures (Sucharitha and Estari, 2013)
This study aimed to evaluate the stability of Ipomoea reptans leaf extract (IPE) Self-nano Emulsifying Drug Delivery System (SNEDDS)
The result indicated that the particle size of the IPE SNEDDS was ≤100 nm and indicated good physical stability
Summary
Diabetes mellitus as the third most deadly health problem in the world can lead to complications that worsen the body organs condition such as chronic hyperglycemia, long-term damages, dysfunctions, and organ failures (Sucharitha and Estari, 2013). The activity of free radicals can initiate the lipid peroxidation, which stimulates the protein glycation, enzyme inactivation and generates longterm complication of diabetes (Lyons and Jenkins, 1997). The Ipomoea reptans leaf extract indicated the pancreatic protector activity in the streptozotocininduced mice, which makes it considered to contains antioxidant compounds, which are β-carotene, riboflavin, vitamin A, tocopherol, 3-methoxy quercetin, 4-methoxy quercetin polyphenol, and anthocyanin (Hayati et al, 2017; Manvar and Desai, 2013). Self-nano Emulsifying Drug Delivery System (SNEDDS) is a dosage form that can improve the bioavailability of lipophilic compounds that lead to an improvement of its clinical efficacy, simplify permeability of drugs, and lower the dose needed to generate clinical effects (Makadia et al, 2013; Jain et al, 2010). The stability of the IPE SNEDDS was observed by conducting centrifugation test, heating-cooling cycle test, freeze-thaw cycle test that aims to review the physical stability and to obtain the stable IPE SNEDDS formula
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