Abstract
This study aims to investigate the stability of florfenicol using previously developed derivative spectrophotometric methods (D1 and D2). The studied stability-indicating pararmeters included alkali (NaOH, 1M), acid (HCl, 1M), pH changes (buffer pH 2.2-11), temperature (80°C and 100°C at pH 10) and light. A constructed pH profile for the drug degradation rate revealed a significant effect of pH on the drug stability between pH ranges 8 and 11. The obtained profile indicated first order dependence of Kobs on [OH-]. Arrhenius plot at pH 10 was found linear at temperatures 80°C and 100°C with estimated activation energy of 19.35kcal/mol. The calculated rate constant (Kobs), t½ and t90 at 25°C were found to be 1.8×10-3h, 385h and 58.3h, respectively. The photostability of florfenicol was also studied by exposing the drug solution to direct sunlight during mid-day time. The obtained results reflected the instability of florfenicol under the study conditions.
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