Abstract
To our knowledge, there are no significant published data on the long-term stability of stored whole blood for hemoglobin A1c (HbA1c) analysis Stored hemolysates (1) and buffy coat samples (2) can provide reliable estimates of HbA1 and HbA1c, respectively; in large epidemiologic studies, however, storage of whole blood would be more practical. A recent report stated that whole blood was stable at −70 °C for 1 year, but no evidence was cited (3). The aim of this study was therefore to test the hypothesis that whole blood is stable at −70 °C for 1 year for HbA1c measurement. Venous blood was collected from 99 children (age, 10 years) without diabetes over a 3-week period in the Avon Longitudinal Study of Parents and Children (ALSPAC; www.alspac.bris.ac.uk). The anticoagulant used was lithium heparin. Available blood was …
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