Abstract
The influence of pH and various buffer species (acetate, borate, citrate and phosphate) on the stability of thymopentin in aqueous solution at 50°C has been studied using a stability-indicating high-performance liquid Chromatographie method. This analytical procedure shows a linear response range at concentrations of 50–200 μg/ml with a correlation coefficient greater than 0.999. The observed rate of degradation was found to follow apparent first-order kinetics with respect to thymopentin. An exact pH optimum of thymopentin in aqueous solution cannot be defined. The peptide shows a similar stability at pH ranges of approximately 5.5–8.0. These stability plateaus can be observed in all buffer systems. The influence of the various buffer species was shown to be different. Acetate has the most favourable effect on stability while phosphate causes greater degradation.
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