Abstract
The aim of our study was to determine the stability of ten antineoplastic drugs stored in their initial package, in conditions of temperature which may be encountered during transport to hospital pharmacy or storage. Stability was determined by high-performance liquid chromatography after storage at cold temperature (+ 4°C) and warm temperature ( + 33°C) for 6 or 12 months comparatively to room temperature ( + 21°/ + 23°C) as recommended by the manufacturers. No change in color was observed in any sample throughout the study except for a yellow hue in fluorouracil vials stored at + 33°C. With the exception of melphalan, all the drugs were stable when stored at both temperatures for 6 and 12 months. Melphalan concentration decreased to less than 90% of theoretical concentration from 6 months storage at + 4°C. In spite of the yellow hue which developed in the fluorouracil vials stored at + 33°C, this drug was found at greater than 90% of the theoretical concentration. Among the ten drugs assayed for stability at unusual temperatures, eight were found to be stable. Two displayed temperature sensitivity as shown by change of color or loss of drug. Temperature should be controlled during storage and transport of drugs, particularly for fluorouracil and melphalan.
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