Abstract
Curcuma Longa L. has been considered as an excellent source of curcumin, having wide scale applications in pharmaceutical, food and cosmetic industry. However, widespread applications of this relatively efficacious agent have been limited due to the poor aqueous solubility, and consequently, minimal systemic bioavailability. In this research, ‘submicron curcumin’ suspension in aqueous media was prepared from Curcuma longa L. without the presence of any additive. The average diameter of the ‘submicron curcumin’ particles was 546 nm (DLS). It was found that the ‘submicron curcumin’ suspension could be used in conjunction with several common food ingredients with its stability remaining unaffected. As the system only contained ‘submicron curcumin’ and water, it would be highly promising to applications in functional food, cosmetic, and pharmaceutical industries.
Highlights
Curcumin has attracted a considerable attention in recent years due to its great variety of beneficial biological and pharmacological activities [1]
A mixture of curcumin, oleoresin, and essential oil from Curcuma longa L. was extracted into 98% ethanol, according to slightly modified previous procedures
2 4 6 8 10 12 14 16 Day stability of ‘submicron curcumin’. With this result in mind, we investigated the stability of ‘submicron curcumin’ in the presence of some common ingredients that could be used or could be contaminated in food products
Summary
Curcumin has attracted a considerable attention in recent years due to its great variety of beneficial biological and pharmacological activities [1]. Attempts to improve water solubility, stability, and bioavailability of curcumin by complex formation or interaction with macromolecules including gelatins, polysaccharides and phospholipids were previously reported [2,3]. Nanoparticle technology has emerged as a potential area of targeted drug delivery systems and made biologically availability of therapeutic agent [4]. Nanoparticles and submicron particles are believed to pass through cell membranes in organisms and get rapid interaction with biological systems. We wish to report the stability of the as-prepared ‘submicron curcumin’ in aqueous media. High pressure steam from an autoclave was injected into the curcumin solution to remove the ethanol and the turmeric essential oil present in the solution. The suspension of ‘submicron curcumin’, being produced during the steam procedure, was cooled to 10 oC to separate and remove oleoresin and conventional curcumin powder
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