Abstract
AbstractThe stability of solids and semisolid dosage forms is characterized by either being a stability of the drug per se, in which case one of the phases of Prout-Tompkins equation holds (leading to either pseudo-first or pseudo-zero order reactions) or by being an interaction. For interactions with water in small amounts, or with trace reactants, an equilibrium is reached. When larger amounts of water are present, then Leeson-Mattocks kinetics hold, and a pseudo-zero order reaction applies.
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