Abstract
Dexamethasone acetate (9α-fluoro-16α-methyl11β,17,21-trihydroxy-1,4-pregnadiene-3,20-dione 21acetate, DMA hereafter) (Fig 1) is an active pharmaceutical ingredient frequently used as an antiinflammatory against rheumatism pains, asthma or even cancer pains. This molecule presents an original behavior during its crystallization in specific conditions. For example, an ethanolic saturated solution of DMA injected in water (anti-solvent) [1] leads to the formation of hollow needlelike crystals called whiskers. At present, the mechanism of formation of these “whiskers” remains not fully understood [1, 2].
Highlights
IntroductionDexamethasone acetate (9α-fluoro-16α-methyl11β,17,21-trihydroxy-1,4-pregnadiene-3,20-dione 21acetate, DMA hereafter) (Fig 1) is an active pharmaceutical ingredient frequently used as an antiinflammatory against rheumatism pains, asthma or even cancer pains
Dexamethasone acetate (9α-fluoro-16α-methyl11β,17,21-trihydroxy-1,4-pregnadiene-3,20-dione 21acetate, DMA hereafter) (Fig 1) is an active pharmaceutical ingredient frequently used as an antiinflammatory against rheumatism pains, asthma or even cancer pains.This molecule presents an original behavior during its crystallization in specific conditions
The stability of DMA solid phases were investigated with the help of X-Ray powder diffraction under variable temperature and relative humidity [3], single crystal XRay diffraction, Dynamic Vapor Sorption [4,5,6] and TGDSC
Summary
Dexamethasone acetate (9α-fluoro-16α-methyl11β,17,21-trihydroxy-1,4-pregnadiene-3,20-dione 21acetate, DMA hereafter) (Fig 1) is an active pharmaceutical ingredient frequently used as an antiinflammatory against rheumatism pains, asthma or even cancer pains. This molecule presents an original behavior during its crystallization in specific conditions. An ethanolic saturated solution of DMA injected in water (anti-solvent) [1] leads to the formation of hollow needlelike crystals called whiskers. The mechanism of formation of these “whiskers” remains not fully understood [1, 2]
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