Abstract
The determination of bone metabolism markers is useful in monitoring pharmacological therapy for osteoporosis (1)(2)(3). During the course of multicenter clinical studies designed to evaluate the therapeutic efficacy of several drugs, it often is useful to carry out analysis in batches after storing the samples for differing periods, thus reducing analytical variation and cost. This requires knowledge of the behavior of the analyte in the biological matrix in terms of the length and conditions of storage. Unfortunately, these data frequently are lacking, and the information provided by a kit’s manufacturer more often than not is contradictory. Data published relative to long-term storage in biological matrices of bone turnover markers, including the seric NH2-terminal propeptide of type I procollagen (P1NP), the urinary cross-linked N-telopeptides of type I collagen (NTx), and the urinary pyridinium cross-links pyridinoline (PYD) and deoxypyridinoline (DPD), are extremely scarce (4). Therefore, our aim was to systematically study the molecular stability of these analytes in the storage mode most frequently used. In particular, the stability of storage lengths …
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