Abstract
Citrated porcine plasmas, when incubated at 37°, lose their factor VIII activity as a function of time. This loss of activity is a first order process and the half-life of the factor VIII activity from von Willebrand (vWd) pigs (∼6 h) is shorter than the half-life of factor VIII from normals (∼ 14 h). After stimulation of a vWd pig by transfusion a factor VIII activity is found with an extremely short half-life (∼ 2.5 h). Carriers of porcine vWd disease have both a labile and stable fraction of factor VIII.
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