Abstract
IntroductionPantoprazole is a weak base (pka∼4) with its stability in aqueous solution dependent on pH. Keeping in mind that the pH of the parenteral nutrition units (PNU) can range between 6.0 and 6.5 and since pantoprazole seems to be the most stable proton pump inhibitor (PPI) for pH acid, we want to assess the possibility of adding it to PNU with the aim of simplifying its administration to patients. MethodsUsing high performance liquid chromatography (HPLC) to measure pantoprazole content in PNU at different time intervals. ResultsThe chromatographic determination of pantoprazole concentration reflected a rapid and progressive aging of the sample. After 24h the quantity of drug detected in the PNU was below 50% of the total added. ConclusionsIn view of these results, we therefore do not suggest this as a suitable vehicle for pantoprazole administration as it could put patients at risk of being under-dosed and therefore exposing them to potential unknown side effects of the different drug degradation products.
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