Abstract
Ondansetron is a serotonin receptor antagonist used in the treatment of chemotherapy-induced emesis1; the addition of dexamethasone increases the antiemetic efficacy.2 Advance preparation of intravenous solutions by a centralized intravenous additive service might improve quality assurance.3 Two studies have reported the stability of ondansetron stored at −20 °C.4,5 Our study investigated the stability of the combination of ondansetron hydrochloride plus dexamethasone sodium phosphate in dextrose 5% in polyolefin bags after freezing, microwave thawing, and long-term storage at 5 ± 3 °C.
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