Abstract
The aim of this study was to investigate the stabilities of two kinds of solutions of nafcillin sodium (2.5 mg/mL) in 0.9% sodium chloride solution (NS, normal saline) and in injectable 5% dextrose water (D5W) in the intravenous elastomeric infusion device (Accufuser?) based on recommended solutions and storage periods. The injectable nafcillin solutions (NS- and D5W-nafcillin) in the Accufuser? device were stored and evaluated at controlled temperatures (room temperature, RT, 5℃ ± 2℃ and cold temperature, CT, 4℃ ± 2℃) during 6 weeks. Effects of the periods of storage (from 0 to 6 weeks) and the temperatures of storage (RT and CT) on the physicochemical appearances and concentrations of active compounds were determined. The visual clarity, pH, and concentrations of nafcillin sodium were determined by stability-indicating high-performance liquid chromatography (HPLC)-ultraviolet (UV) detection. The results showed that in NS and D5W solutions, the amount of nafcillin slightly changed and remained 92.66% and 97.30% of their initial amounts at CT during 6 weeks, respectively. On the other hand, in NS and D5W solutions at RT, the amount significantly decreased with time and reached 27.66% and 31.97% of their initial amounts during 4 weeks, respectively. Slight decrement of pH was observed in CT storage while significant change was observed in the RT storage. Moreover, in CT, no significant changes in physical appearances and colors of the solutions were observed during the study. However, the solutions changed into yellowish color and some particles were detected in both kinds of nafcillin solutions (NS and D5W) after 1.5 weeks in RT conditions. To sum up, under CT two kinds of nafcillin sodium solutions (NS and D5W) were stable with time in Accufuser? without any significant physical changes and retained almost all of the initial concentrations up to 6 weeks. However, the solutions were not stable in RT storage. We suggest that nafcillin sodium solutions in an Accufuser? should be preferentially diluted in NS and D5W while storing in CT condition.
Highlights
IntroductionThe disposable silicon balloon infusion device (Accufuser®, Woo Young Medical Co. LTD., Seoul, South Korea) is a well-established simplified silicon-based elastomeric system for the administration of antibiotics and other drugs or nutrients that are suitable for patients as well as healthcare providers
We suggest that nafcillin sodium solutions in an Accufuser® should be preferentially diluted in NS and D5W while storing in CT condition
The disposable silicon balloon infusion device is advantageous in home health care setting because it is disposable, relatively inexpensive compared to electronic pumps, and it is easy for the patient to fill and manipulate [3]
Summary
The disposable silicon balloon infusion device (Accufuser®, Woo Young Medical Co. LTD., Seoul, South Korea) is a well-established simplified silicon-based elastomeric system for the administration of antibiotics and other drugs or nutrients that are suitable for patients as well as healthcare providers. An increasing number of patients are being treated as outpatients, and for them, drugs are often infused using portable pumps or infusion devices outside the hospital [1,2]. The disposable silicon balloon infusion device is advantageous in home health care setting because it is disposable, relatively inexpensive compared to electronic pumps, and it is easy for the patient to fill and manipulate [3]. In contrast to hospital practice, infusion-pump drug reservoirs in temporary clinic or home care setting are routinely loaded with sufficient doses of a drug, which may last for 24 hours or more, and it is not easy to check the solutions for the stability of the drug content [4]. The study was done with nafcillin sodium solutions made with NS and D5W because these are the most available infusion solu-
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
