Abstract
The stability of methotrexate (MTX) injection in 4 commercially available brands of sealed plastic disposable syringe has been investigated. MTX injection at a concentration of 50 mg/ml or less, stored in sealed Monoject (Sherwood Medical) or Plastipak (Becton Dickinson), plastic disposable syringes in the absence of light at a temperature not exceeding 25 °C was found to be stable (less than 10% degradation) for a period of up to 8 months. A possible alteration in the permeability of the syringe material to water vapour on prolonged storage in contact with MTX solution precluded storage in Sabre (Gillette) or Steriseal (N.I. Ltd.) syringes for more than 70 days at 25°C. Sealed plastic disposable syringes are, therefore, a suitable secondary packaging system for the storage of MTX injection for periods of up to 8 months.
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