Abstract
Four kinds of fat emulsions for intravenous injection in the market were preserved under the following three conditions: at 7°, 20° and 30°C in light-resistant containers. Under these conditions the time-course changes in a particle shape, pH, peroxide and free fatty acid were studied for 6 months. No time-course changes in the particle shape were observed in all of 4 products at the 3 different temperatures while pH value was decreased slightly with time at 30°C. No significant difference was observed in peroxide at any of the temperatures, but free fatty acid concentration was apparently increased at 30°C. From these results, it seems that fat emulsions for intravenous injection is recommended to be kept in a cold place.
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