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Abstract
SUMMARY: Breakdown of DNA to acid-soluble fragments induced in strains of Escherichia coli b by nalidixic acid (10 μg./ml.) differed in linear rate according to the ability of the strain to repair DNA lesions. Strains which were exr (bs-2) and exr, uvr (bs-i) exhibited excessive DNA breakdown following nalidixic add treatment. The excision-defective uvr strains, bs-8, bs-12 and wwp-2 her, also degraded their DNA to acid-soluble fragments at a rate which initially was greater than that of the parental strain (E. coli b). This degradation was unaffected by the rad mutation. Removal of nalidixic acid from the system considerably lowered the rate of DNA breakdown. The responses to nalidixic acid and other agents potentiating DNA breakdown are compared.
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