Abstract
The stability of aspirin in methoxypolyetbylene glycol, polyethylene glycol acetate, or a mixture of polyethylene glycols was studied at three temperatures. Degradation proceeded to the highest extent in a mixture of polyethylene glycols and to a lesser extent in methoxypolyethylene glycol. Degradation in polyethylene glycol acetate for 30 days at 45° was insignificant. The data confirm that decomposition of aspirin in polyethylene glycol is due primarily to a transesterification reaction.
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