Abstract
Ciprofloxacin is a modern effective antibacterial drug widely used for the treatment of infectious disorders. In acute cases, ciprofloxacin is administered in the form of an infusion preparation containing 200 mg of the parent drug in 100 ml of isotonic solution [1]. Foreign manufacturers prepare the infusions using ciprofloxacin base with lactic acid added as the stabilizer. In some cases (ciprova, ciprofloxacin infusion solution from Lupin Laboratories Ltd., India), the preparation is additionally stabilized by adding sodium-EDTA salt. The aim of this study is to develop the optimum composition of an infusion preparation of ciprofloxacin hydrochloride using sodium chloride isotonic solution and MacIlvaine buffer (containing citric acid and sodium hydrophosphate) for maintaining the optimum pH value [2].
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