Abstract

Acetaldehyde was found to disappear rapidly in human venous blood samples when added in concentrations ranging from 10 to 50 μ m. The disappearance was dependent on temperature and the presence of blood cells. Evidence is presented for the conversion of acetaldehyde to acetate. By contrast, acetaldehyde which accumulates in human venous blood samples from the metabolism of ethanol in vivo did not disappear under conditions where added acetaldehyde disappeared rapidly. It is suggested that acetaldehyde formed from ethanol in vivo may be bound reversibly to blood constituents.

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