Abstract
Loxoprofen sodium was analyzed using UV spectrophotometry, and the method was designed and validated in the present study in accordance with ICH Q2 recommendations. Loxoprofen sodium’s stress degradation behavior was investigated using a newly discovered technique. Analysis was carried out at 223 nm by using distilled water as solvent. Stress degradation of drug was studied at acidic, basic and oxidative conditions. With a correlation coefficient of 0.999, linearity was found between 5 and 25 μg/mL. Intraday and interday precision studies showed RSD values of <0%, demonstrating the accuracy of the presented approach. Results obtained for LoD and LoQ are 0.012 and 0.037 μg/mL, respectively. For the ruggedness study, the absorbance value of six replicates was found to be 0.477 ± 0.004 with %RSD > 2.0% states that the developed method was found to be rugged. During the stress degradation study, it was observed that the drug is susceptible to basic and oxidative conditions with degradation of more than 10%.
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