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Abstract
IntroductionLafutidine is a H2 receptor antagonist and is indicated for inhibition of acid secretion. UV spectrophotometry can be used for stress degradation studies of lafutidine. MethodLafutidine was subjected to different stress conditions as per International Conference on Harmonization (ICH) guidelines. A stability-indicating UV spectroscopic method was developed for analysis of the drug in the presence of the degradation products. It involved a 5-h study; in which methanol and distilled water were used as solvents. The amount of degraded drug was calculated by taking absorbance at 279 nm. ResultsDegradation of lafutidine was found to occur in alkaline, neutral and photolytic conditions whereas it was found to be stable in acidic condition ConclusionThe method was found to be simple and cost effective. Hence this method can be successfully used to study stress degradation behavior of lafutidine in small industry where high end instruments are not available.
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