Abstract
A novel simple rapid accurate and precise UV spectrophotometric method for simultaneous estimation of bromhexine hydrochloride (BRH) and phenylephrine hydrochloride (PHE) in combine tablet dosage form have been developed. BRH shows absorbance maxima at 246nm and PHE shows 272nm in distilled water after sonication for 20 min. Beer`s law was obeyed at the range of 4-24µg/ml and 5-30µg/ml by BRH and PHE respectively. The method was validated as per ICH guidelines. The validation study data was found to be statistically significant as all the statistical parameters are within the acceptance range (% RSD < 2.0 and S.D. < 2.0) for both accuracy and precision. The force degradation study was carried as per ICH guidelines. The proposed method can be successfully applied for the routine analysis of commercial marked formulation.
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