Abstract
A stability-indicating method of analysis for homatro-pine methylbromide in pharmaceutical formulations containing antacids was developed. The method is based upon the extraction of homatropine methylbromide with methanolic hydrochloric acid, followed by reaction with a modified Dragendorff reagent. The iodobismuthate complex is measured spectrophotometrically in a stabilized methanol-acetone solution at 382nm. A homatropine methylbromide degradation product was isolated from these formulations and identified as tropine methylbromide. The Dragendorff method of analysis was found to be selective for homatropine methylbromide in that there was no interference from its major decomposition product.
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