Abstract
A simple, accurate and precise reverse phase ultra-performance liquid chromatography method was developed and validated for simultaneous estimation of Pregabalin and Etoricoxib in formulations as well as in pure form. The developed method was shown acceptable separation of pregabalin and Etoricoxib. The retention times for Pregabalin and Etoricoxib were 1.134 min. & 1.535 min. respectively. The limits of detection and quantification were obtained from regression equations and observed to be 0.85ppm and 0.54ppm for Pregabalin, 2.58 and 1.62ppm for Etoricoxib, respectively. Degradation studies of the tablet dosage form under stress conditions of acid, base, oxidation , temperature, water, UV light indicated that the method was particular with no interferences from any of the potential impurities that could form over the shelf life. The new developed RP-UPLC method which was sensitive, accurate stability indicating and fast, for active pharmaceutical ingredients and dosage forms. Key words: Pregabalin, Etoricoxib, Simultaneous, Reverse Phase - UPLC
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