Abstract
BackgroundThe aim of this study was to examine the stability and relative validity (RV) of the Neuromuscular Disease Impact Profile (NMDIP) using criterion-related groups. In a previous study the NMDIP-scales showed good internal consistency, convergent and discriminant validity. Known-groups analysis showed that the NMDIP discriminates between categories of extent of limitations.MethodsA cross-sectional postal survey study was performed on patients diagnosed with a NMD and registered at the Department of Neurology, University Medical Center Groningen, the Netherlands.Participants were asked to complete the preliminary NMDIP, the Medical Outcome study Short Form Questionnaire (SF-36), the World Health Organization Quality Of Life-abbreviation version (WHOQOL-bref), and two generic domain specific measures: the Groningen Activity Restriction Scale (GARS) and the Impact on Participation and Autonomy Questionnaire (IPAQ). The variables ‘Extent of Limitations’ and ‘Quality of Life’ were used to create criterion-related groups. Stability over time was tested using the Wilcoxon Signed Rank Test for paired samples and the intraclass correlation coefficients for repeated measures. RV was examined by comparing the ability of NMDIP with generic multidimensional health impact measures, and domain specific measures in discriminating between criterion-related subgroups using the Kruskal-Wallis H-test.ResultsResponse rate was 70% (n = 702). The NMDIP-scales showed sufficient stability over time, and satisfactory or strong RV. In general, the NMDIP scales performed as well as or better than the concurrent measurement instruments.ConclusionsThe NMDIP proved to be a valid and reliable disease-targeted measure with a broad scope on physical, psychological and social functioning.
Highlights
The aim of this study was to examine the stability and relative validity (RV) of the Neuromuscular Disease Impact Profile (NMDIP) using criterion-related groups
The Neuromuscular Diseases (NMD) category distribution differed significantly between the samples with less patients with Motor-neuron disorders and Muscle disorders and more patients with Peripheral nerve disorders in the total sample compared to the test-retest sample
We examined the performance of the NMDIPscales in indicating the differences between extreme groups (A-D) and subgroups (A-B, B-C, C-D) regarding the physical, psychological- and social functioning constructs, as they relate to similar constructs in the concurrent measurement instruments
Summary
The aim of this study was to examine the stability and relative validity (RV) of the Neuromuscular Disease Impact Profile (NMDIP) using criterion-related groups. In a previous study the NMDIP-scales showed good internal consistency, convergent and discriminant validity. Known-groups analysis showed that the NMDIP discriminates between categories of extent of limitations. Neuromuscular Diseases (NMDs) may be caused by an abnormality of the anterior horn cells, sensory ganglion cells (neuronopathy), the peripheral nerves (neuropathy), neuromuscular junctions (myasthenia), or muscle (myopathy). The NMDIP consists of 36 items that cover all ICFcomponents and are divided into eight scales and four single items. The NMDIP-scales showed moderate to good Cronbach’s alpha and mean inter-item correlation coefficients. Convergent and discriminant validity analysis indicated that the NMDIP measures the impact of neuromuscular disease on physical, psychological and social functioning. The NMDIP discriminates between groups of patients who differ in ‘Extent of limitations’. The four single items represent the Environmental Factors component (three items) and one Body Functions item (Seeing function) [4]
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