Abstract
A rapid isocratic technique was developed for the analysis of fluoroquinolones (pefloxacin, ofloxacin and ciprofloxacin) in parenteral solutions using high-performance liquid chromatography (HPLC) with fluorimetric detection and a C 18 column. The availability and compatibility of drugs from solutions infused via plastic infusion bags through plastic administration sets have been examined. No significant drug loss was observed during simulated infusions ( n = 4) for 1 h using PVC infusion bags and administration sets. No significant difference was found between infusion solutions (5% glucose or 0.9% NaCl). The stability of drugs was also studied in solution in PVC bags after storage at room temperature without protection from light. The results show the stability of pefloxacin and ciprofloxacin during 6 h of storage to be satisfactory, irrespective of the infusion solution (5% glucose or 0.9% NaCl). However, we have observed more significant variations with ofloxacin in the solution of 5% glucose, but remaining below 10%.
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