Abstract
ABSTRACT The Effect of Hwangnyeonhaedok-tang Pharmacopuncture on ST25 (天樞) in Rats with Dextran Sulfate Sodium (DSS)-Induced ColitisSeung-Heon Lee, Kyung-Mi Park, Seong-Hee ChoDae-Hwan Youn, Seung-Jeong YangDept. of Oriental Obstetrics & Gynecology, College of Korean Medicine, Dong-Shin UniversityObjectives: The purpose of this study is to find out the effect of various concentrations of Hwangnyeonhaedok-tang (HTT) pharmacopuncture on ST25 (天樞) in rats with dextran sulfate sodium (DSS)-induced colitis.Methods: Colitis was experimentally induced by feeding rats with water mixed with 5% (w/v) DSS for 20 days. The rats were divided into 5 gro ups: the normal group (Nor, n=5), the control group - colitis induced rats with no treatment (Con, n=5), the acupuncture group - colitis induced rats with acupunc ture applied on ST25 (Acu, n=5), the pharmacopunc ture group 1 - colitis induced rats with 0.729 mg/250 g/40 μl of pharmacopuncture applied on ST25 (PA-1, n=5), the pharmaco puncture group 2 - colitis induced rats with 3.645 mg/250 g/40 μl of pharmacopuncture applied on ST25 (PA-2, n=5). The changes in weight, excrement concentra tion and hemafecia were observed 5 times every 2 days. The colon lengths were meas ured from appendix to the end of colon after the experiment. Hematological and ser ological exams were conducted the day after the last treatment by cardiac puncturin g anesthetized rats.Results: ST25 is the abdominal front point (募穴) of large intestine meri dian and is known to have effect in colitis. Various concentrations of H TT pharmacopuncture (HTTP) applied on ST25, in rats with DSS-induced colitis inhibi ted decrease in colon lengths and body weight in both PA-1 and PA-2 groups. Hematological and serological exam results also showed that HTTP has signific ant effect on colitis in both PA-1 and PA-2 groups.Conclusions: Colon lengths were significantly increased in the acupuncture group, PA-1 group and PA-2 group, compared to the control group. The b ody weight was significantly increased (p<0.05) in PA-2 group after the first treatment, compared to the control group. TNF- 𝛼, IL-6, AST were significantly decreased in PA-1 and PA-2 groups, compared to the control group.Key Words: colitis, dextran sulfate sodium (DSS), ST25, Hwangnyeonhaedok-tang pharmacopuncture (HTTP)
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