ST2 as a predictor of late ventricular remodeling after myocardial infarction

Abstract

Out of 163 STEMI patients, 33 presented left ventricular remodeling (LVR) as assessed by multiple cardiac magnetic resonance (CMR) scans. LVR patients were identified as EarlyLVR (LVR occurring between baseline and 3 months) or LateLVR (LVR occurring between 3 months and one year), and matched to non-remodeler patients in term of age, gender, anterior infarction, baseline LV ejection fraction and infarct size. ST2 and NT-proBNP were measured at baseline and 3 months. Systolic wall stress (SWS) was calculated by CMR.At baseline, mean levels of ST2, NT-proBNP and SWS were 67.1 ± 54.1 ng/mL, 1529 ± 1702 ng/L and 17.9 ± 7.1 103 N·m−2, respectively, and did not differ among the groups. At 3 months, EarlyLVR patients presented significant higher ST2, NT-proBNP and SWS (31.6 ± 12.7 ng/mL, 1142 ± 1069 ng/L, 25.5 ± 9.7 103 N·m−2), compared to the corresponding non-remodelers (20.5 ± 8.6 ng/mL, 397 ± 273 ng/L, 18 ± 7.3 103 N·m−2; with p = 0.017, 0.040, and 0.036, respectively). LateLVR patients presented higher ST2 at 3 months than their non-remodelers (33.6 ± 15.9 versus 23.66 ± 8.7 ng/mL, p = 0.046), while NT-proBNP and SWS were not different between groups at both timepoints.