Abstract
Physiologic responses of tissue engineered blood vessels (TEBV) seeded with endothelial cells (EC) remains suboptimal compared to native arteries due to lack of smooth muscle cells (SMC) in the vessel media. Thus, there may be benefit to incorporating SMCs into TEBV. In vitro studies have shown limited vasomotor activity in SMC seeded TEBV. The goal of the present study was to evaluate the impact of SMC co-seeding on TEBV structure and function after prolonged in vivo maturation.
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