Abstract
Sepsis affects 750,000 patients in the US annually, associated with a mortality rate of up to 30%. The pathophysiology of sepsis is complex. The “cytokine theory,” which deems the host’s immune response to infection as the main cause of septic death, has been the focus over the past decades. However, more recent studies indicate that sepsis associated metabolic derangements due to hypoxic tissue injury, impaired oxygen utilization, and mitochondrial dysfunction also contributes to mortality. Sirt1 is a crucial modulator of energy metabolism, identified from its beneficial role on longevity during caloric restriction.
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