Abstract
SRSF1 inhibition of HIV-1 gene expression.
Highlights
The treatment of HIV-1 infected patients is mostly based on compounds that directly target the activity of proteins coded by the virus
In recent work we screened a RNA Binding Protein (RBP) expression library to identify cellular proteins that modulate the replication of HIV-1 [2]
SR proteins are widely expressed in eukaryotes and regulate gene expression by controlling the assembly of the splicing machinery, integrating multiple steps in RNA metabolism and modulating RNA Polymerase II (RNAPII) activity [3]
Summary
The treatment of HIV-1 infected patients is mostly based on compounds that directly target the activity of proteins coded by the virus. Genomic screenings utilizing siRNA libraries have helped in the identification of several cellular proteins required for HIV-1 replication and infectivity [1]. An alternative approach is the screening of complementary DNA libraries for genes that inhibit viral replication.
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