Abstract
Cancer is one of the most deadly and widespread diseases nowadays. Local cancer treatments are gaining strong importance. Magnetic Drug Targeting and magnetic heating treatment are minimal invasive cancer treatments that make use of magnetic nanoparticles as drug carriers in the first case and to induce heat transfer in the second case. For MDT the application of drugs, bound to magnetic nanoparticles, is realized via the tumor supplying vessels while a strong magnetic field gradient influences the flow and directs the nanoparticles to the respective region. In order to understand the mechanisms behind this magnetically controlled drug delivery, an ex-vivo artery model has been established. To study the amount and the distribution of magnetic nanoparticles within the arteries, microcomputed tomography and magnetorelaxometry have been used as analytical techniques. MRX provides very sensitively the amount of magnetic nanoparticles, while microcomputed tomography based on a synchrotron beam line enables 3-dimensional non-destructive examination of the distribution of the magnetic nanoparticles at a spatial resolution of a few micrometers. In this paper we present first results concerning the quantitative study of accumulation of nanoparticles within bovine arteries streamed with magnetic nanoparticles.
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