Sürekli Ambulatuar Periton Diyalizi Hastalarında Isoflavonların Paraoksonaz ve Adiponektin Üzerine Etkileri

Abstract

Objective: The level of oxidative stress may increase improperly in chronic pathological conditions such as atherosclerosis, hypertension and uremia. Increased production of reactive oxygen radical species and/or failure of antioxidant systems contribute to the pathogenesis of chronic renal failure. The aim of this study was to investigate the effects of isoflavone, which has antioxidant properties, on oxidative-antioxidative system in patients with chronic renal failure who underwent continuous ambulatory peritoneal dialysis (CAPD). Material and Methods: Thirty patients who underwent CAPD were included in the study. Three patients were excluded from the study, two patients due to gastrointestinal complaints and one patient due to renal transplantation. The remaining 27 patients received 40 mg oral soy isoflavones (Isoflavin® tablets, Micro-Gen) twice daily for 10 weeks. The levels of total cholesterol, triglyceride, LDLcholesterol, HDL-cholesterol, hs-CRP, oxidized LDL, malondialdehyde, adiponectin, paraoxonase and arylesterase were measured and analyzed statistically before and after isoflavone treatment. Results: There was a statistically significant decrease in serum total cholesterol, LDL-cholesterol and triglyceride levels after treatment (p <0.001, p=0.005, p <0.001, respectively). There was a statistically significant decrease in hs-CRP levels, which is one of the markers of inflammation, and oxidized LDL and malondialdehyde levels, which are oxidative stress markers, compared to pretreatment levels (p <0.001, p<0.001, p=0.04, respectively). The levels of adiponectin, paraoxonase and arylesterase, which have antioxidative properties, increased significantly after treatment compared to pre-treatment levels (p=0.002, p=0.03, p <0.001, respectively). Conclusion: The use of soy isoflavones, which have antilipogenic, antihypertensive and vascular health-enhancing properties, may provide beneficial effects on inflammatory and atherogenetic processes by obtaining positive effects on antioxidative system in patients with chronic renal failure.