Abstract
Objective To determine whether Fyn expression was altered in human esophageal squamous cell carcinoma (ESCC) TE1 cell line by TomL1. Methods We transfected 0, 0. 25, 0. 5,1.0, and 2.0 μg Srcasm plasmid DNA into TE1 cells and examined Fyn/Srcasm expression by Western blotting. Results Srcasm decreased the Fyn protein expression in TE1 cells in a dose-dependent manner.Conclusion Srcasm may act as a negative regulator of Fyn in human ESCC, and play an important role in human ESCC progress. Key words: Esophageal/neoplasms; Tyrosine kinases; Srcasm
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