Src Regulates Nicotine Induced Inhibitor of DNA-binding Protein Id1 Expression In Pancreatic Adenocarcinoma Cells

Abstract

Introduction: DNA-binding protein inhibitor Id1 is a helix-loop-helix (HLH) protein which plays a role in cell growth, senescence, and differentiation. Overexpression of Id1 correlates with aggressive phenotypes and tumor progression in several human cancers. Although previous reports have demonstrated that Id1 correlates to tumor angiogenesis in pancreatic adenocarcinoma, the signaling pathways related to these events remains unidentified. Previous reports have demonstrated Src and its family of non-receptor protein tyrosine kinases (SFKs) play a critical role in angiogenesis and tumor progression in pancreatic adenocarcinoma.