Abstract
Our understanding of the molecular basis of G protein-coupled receptors (GPCRs) activation and signaling has exploded over the last few years. X-ray crystallography and single-particle cryo-electron microscopy have provided static structural snapshots for a range of receptor conformational states and receptor-signaling partner complexes (1). In parallel, a combination of biophysical techniques and computational studies have revealed that GPCRs are highly dynamic allosteric proteins that sample complex conformational landscapes (2).
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