Abstract
In this paper the determination of acetylsalicylic acid (ASA) in pharmaceutical formulations using square-wave voltammetry (SWV) and a boron-doped diamond electrode (BDD) is described. By this proposed method, ASA is directly determined in a 0.01 mol L-1 H2SO4 solution without the need of a previous time-consuming alkaline hydrolysis step. A single oxidation peak at a potential of 1.97 V vs. Ag/AgCl (3.0 mol L-1 KCl) with the characteristics of an irreversible reaction was obtained. The obtained analytical curve is linear in the ASA concentration range 2.50 × 10-6-1.05 × 10-4 mol L-1, with a detection limit of 2.0 µmol L-1. The obtained relative standard deviation was smaller than 1.4% for a 45 µmol L-1 ASA solution (n = 10). The proposed method was applied with success in the determination of ASA in several pharmaceutical formulations; the obtained results were in close agreement, at a 95% confidence level, with those obtained using an official method of the British Pharmacopoeia.
Highlights
Acetylsalicylic acid (ASA), shown in Figure 1, more popularly known as aspirin, is one of the oldest medicines that still plays an important role in modern therapeutics
Since the response in the H2SO4 solution is characterized by a well-defined oxidation peak, this solution was chosen as the suitable medium for further experiments
The obtained results showed that the peak current presents a maximum value for 0.01 mol L-1
Summary
Acetylsalicylic acid (ASA), shown in Figure 1, more popularly known as aspirin, is one of the oldest medicines that still plays an important role in modern therapeutics. This electrode showed a linear response to ASA in the concentration range 4.0 × 10-3 mol L-1 to 4.0 × 10-2 mol L-1, with an analytical frequency of 28 samples h-1.
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