Abstract
The adsorptive stripping voltammetry of telmisartan was investigated with a hanging mercury drop electrode. This compound produced a catalytic hydrogen wave at -1.5 V in Britton Robinson buffer of pH 10.38, and the peak current increased with adsorptive accumulation at the electrode. Adsorptive stripping voltammetry with the catalytic hydrogen wave could provide a sensitive novel method for the determination of telmisartan. Various chemical and instrumental parameters affecting the monitored electroanalytical response were investigated and optimized for telmisartan determination. Under these optimized conditions the squarewave adsorptive stripping voltammetric ( SWAdSV ) peak current showed a linear dependence on drug concentration over the range 0.05-3.00 µg/mL (1 × 10 -7 ⎯6 × 10 -6 M) (r = 0.999) with accumulation for 120 s at -1.0 V vs. Ag/AgCl. The proposed electrochemical procedure was successfully applied for the determination of telmisartan in pharmaceutical tablets and human plasma. The results of the developed SW� AdSV method were comparable with those obtained by reported analytical procedures.
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