Abstract
AbstractA new method for the construction of five‐membered spirocyclic oxindoles is based on a Michael–Mannich cascade reaction of a ketimine intermediated catalyzed by a bifunctional quinine‐derived squaramide. The desired products were obtained in excellent yields (up to 94 %) and stereoselectivities (up to >20:1 d.r., >99 % ee). A scaled‐up variant also proceeded smoothly showing that the one‐pot reaction might find application in the synthesis of bioactive‐compound libraries.
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