Abstract
Objective To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer. Design Interventional case report. Methods A full-thickness section of canaliculus was obtained during surgical repair. Main outcome measure Histopathologic changes in the specimen. Results The prominent histologic feature of the canalicular specimen was severe squamous metaplasia with narrowing of the lumen. Conclusion Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia.
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Schedule a callMore From: Transactions - American Academy of Ophthalmology and Otolaryngology
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