Abstract
Squamous Cell Carcinoma of the Tongue in a Patient on Ustekinumab as the Treatment of Psoriasis
Highlights
Psoriasis is a chronic inflammatory dermatosis affecting 2–3% of the general population worldwide
We report a rare case of a patient who developed Squamous Cell Carcinoma (SCC) of the tongue after the commencement of ustekinumab as the treatment of plaque type psoriasis
The RNA scope-based in situ Hybridization (ISH) of Human Papillomavirus (HPV) high-risk and low-risk panels (RNAscope Reagent Kits, Advanced Cell Diagnostics, USA) showed no E6/E7 mRNA transcripts was detected
Summary
It is noteworthy that this patient developed one ulcerative nodular lesion on the right lateral aspect of her tongue (Figure 2) after the treatment of ustekinumab from 2016. No history of previous Human Papillomavirus (HPV) infection (including oral, genital and cutaneous infection) was identified. Betel nut chewing, or alcohol use were noted, either. The lesion was biopsied and histology revealed this lesion to be well to moderately differentiated SCC composed of sheets and nests of neoplastic cells with keratinization and intercellular bridges (Figure 3 and 4). The RNA scope-based in situ Hybridization (ISH) of HPV high-risk and low-risk panels (RNAscope Reagent Kits, Advanced Cell Diagnostics, USA) showed no E6/E7 mRNA transcripts was detected
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