Abstract
Squamous cell carcinoma (SCC) is usually diagnosed in older male patients with a history of alcohol-tobacco abuse, but this epidemiological pattern has been changing over the past decade, younger patients are being diagnosed more often. A 22-year-old female patient, with no history of alcohol-tobacco abuse, was referred to the oral and maxillofacial surgeon by her clinician due to an ulcerated lesion, presenting 2 × 2 cm firm and elevated borders over the past 8 months. An incisional biopsy was made, and the histopathological analysis revealed sheets of epithelial cells displaying an altered nuclei-cytoplasm relation, hyperchromatism, pleomorphism, bizarre mitotic figures, and keratin pearls. Immunohistochemistry stains were performed for P63 (+) and P16(-) with the diagnosis established as SCC. An excisional biopsy with cervical dissection was performed, resulting in pT2pN2b grading. The patient went through 5 weeks of chemoradiotherapy and has been undergoing follow-up for 6 months. Squamous cell carcinoma (SCC) is usually diagnosed in older male patients with a history of alcohol-tobacco abuse, but this epidemiological pattern has been changing over the past decade, younger patients are being diagnosed more often. A 22-year-old female patient, with no history of alcohol-tobacco abuse, was referred to the oral and maxillofacial surgeon by her clinician due to an ulcerated lesion, presenting 2 × 2 cm firm and elevated borders over the past 8 months. An incisional biopsy was made, and the histopathological analysis revealed sheets of epithelial cells displaying an altered nuclei-cytoplasm relation, hyperchromatism, pleomorphism, bizarre mitotic figures, and keratin pearls. Immunohistochemistry stains were performed for P63 (+) and P16(-) with the diagnosis established as SCC. An excisional biopsy with cervical dissection was performed, resulting in pT2pN2b grading. The patient went through 5 weeks of chemoradiotherapy and has been undergoing follow-up for 6 months.
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