Abstract
Cutaneous squamous cell carcinoma (SCC) is a common form of skin cancer and often appears as a hard, scaly lump that occasionally ulcerates. It is usually associated with cumulative exposure to ultraviolet light, although prior scarring, chronic wounds, exposure to radiation, HPV infection, and immunosuppression are also associated risk factors. Primary SCC of the nipple is very rare and only a few cases have been reported. We present a case of a 49-year-old female with concerns of a right nipple lesion with erythema and pain. She was initially evaluated for Paget's disease with an underlying malignancy and cellulitis, but, after biopsy and investigation, she was found to have a well-differentiated SCC arising from a verruca vulgaris. Current literature does not provide distinct guidelines on management of SCC or its variants on the nipple, and the case was managed based off of SCC at other cutaneous sites as well as other cases of SCC on the nipple.
Highlights
Squamous cell carcinoma (SCC) of the skin and basal cell carcinoma of the skin are the most common cancers diagnosed annually in the United States [1]
Cutaneous SCC is a very common diagnosis, to have it occur on the nipple is unlikely
They are usually associated with cumulative exposure to ultraviolet light prior scarring, chronic wounds, exposure to radiation, human papilloma viruses (HPV) infection, smoking, and immunosuppression are associated risk factors
Summary
Squamous cell carcinoma (SCC) of the skin and basal cell carcinoma of the skin are the most common cancers diagnosed annually in the United States [1]. The most common reported risk factor for SCC is cumulative exposure to ultraviolet light [3]. Other risk factors include scarring, chronic wounds, ionizing radiation, HPV infection, and immunosuppression. Cutaneous SCC is usually not fatal, but it is associated with invasion causing local disfigurement and occasionally distant metastases. Primary SCC of the nipple is extremely rare and is noted in English literature only ten times [4,5,6,7,8,9,10,11,12,13]. Management of SCC of the nipple is derived from the understanding of cutaneous SCC in more common areas, a wide variety of treatment modalities has been reported
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