Abstract
Tattoos, a common form of body adornment, have been associated with numerous cutaneous complications. These include not only benign neoplasms and malignant tumors but also lymphoid conditions occurring within the tattoo. Tattoo-associated dermatomyofibroma, epidermoid inclusion cyst, hemangioma, lipoma, milia, and pilomatricoma are benign lesions that have each only been described in one individual. However, there are only a few reports of persons with either dermatofibroma or seborrheic keratoses within their tattoo; also, benign nevi within a tattoo may be more common than the number of reported individuals. In contrast, there are multiple patients with tattoo-associated pseudoepitheliomatous hyperplasia. Lymphoid conditions that have been observed in a tattoo include single patients with either lymphomatoid papulosis or B-cell lymphoma; however, several individuals have been described with pseudolymphoma developing within their tattoo. Tattoo-associated cutaneous cancer predominantly includes individuals with squamous neoplasms (such as keratoacanthomas and squamous cell carcinomas) and malignant melanoma; however, basal cell carcinoma originating within a tattoo is not uncommon. A 57-year-old man is described who received a tattoo on his left forearm 35 years earlier; he subsequently developed a squamous cell carcinoma in the black tattoo ink. In contrast to the patient in this report, tattoo-associated squamous neoplasms usually develop within a median of four weeks after tattoo inoculation, touch-up, or laser-assisted removal. Also, in contrast to the reported patient, tattoo-associated squamous neoplasms are more commonly observed in red tattoos. However, malignant melanoma and basal cell carcinoma more frequently occur in black and darker-pigmented tattoos. In addition, dermatofibrosarcoma protuberans, cutaneous leiomyosarcoma, and invasive breast duct carcinoma cutaneous metastases have each been described to appear within a patient’s tattoo. It remains to be determined whether tattoo inoculation or tattoo pigment, or both have an epidemiologic role in the subsequent development of benign, lymphoid, or malignant lesions within the tattoo. Several observations support either a direct or indirect role of tattooing as a contributing factor and tattoo pigment as a carcinogen in the etiology of tattoo-associated malignancies. Investigation into the possible relationship between tattoos and cancer development is in progress.
Highlights
Squamous cell carcinoma is a common cutaneous cancer
Some of the other risk factors contributing to the development of squamous cell carcinoma include light skin-colored older men, chronic immunosuppression, and exposure to chemical carcinogens [1,2]
In the center of the specimen, there was an extension of the atypical keratinizing epithelium into the underlying, sun-damaged dermis; these findings were those of a squamous cell carcinoma (Figure 2)
Summary
Squamous cell carcinoma is a common cutaneous cancer. Exposure of the skin to ultraviolet radiation, such as sunlight, is a significant cause of squamous cell carcinoma. He had a squamous cell carcinoma in situ excised from his left arm two months earlier His current lesion was located within a black tattoo on his left forearm. In the center of the specimen, there was an extension of the atypical keratinizing epithelium into the underlying, sun-damaged (reflected by solar elastosis) dermis; these findings were those of a squamous cell carcinoma (Figure 2). Squamous cell carcinoma (red oval in the center of the specimen) is demonstrated by the extension of the atypical keratinizing epithelium into the sun-damaged dermis. In the deep reticular dermis, there is dense lymphocytic inflammation and invasion of large aggregates of atypical squamous tumor cells (red triangles) (hematoxylin and eosin: A: x10; B: x20). The excision specimen confirmed that the squamous cell carcinoma had been completely removed and demonstrated additional tattoo pigment in the dermis
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