Abstract
Four cyclic octapeptides, squamins C–F, were isolated from the seeds of Annona globiflora Schltdl. These compounds share part of their amino acid sequence, -Pro-Met(O)-Tyr-Gly-Thr-, with previously reported squamins A and B. Their structures were determined using NMR spectroscopic techniques together with quantum mechanical calculations (QM-NMR), ESI-HRMS data and a modified version of Marfey's chromatographic method. All compounds showed cytotoxic activity against DU-145 (human prostate cancer) and HeLa (human cervical carcinoma) cell lines. Clearly, A. globiflora is an important source of bioactive molecules, which could promote the sustainable exploitation of this undervalued specie.
Highlights
In Mexico, there are about 20 species of Annona genus, mainly located in southeastern tropical regions
A. globiflora is an important source of bioactive molecules, which could promote the sustainable exploitation of this undervalued specie
Within this group of wild native Annona species, we focused the current study on Annona globiflora Schltdl. (Annona ceae)
Summary
In Mexico, there are about 20 species of Annona genus, mainly located in southeastern tropical regions. We report a phytochemical study of the seeds of A. globiflora collected in spring 2018 in Veracruz state (Mexico), in which four pre viously unreported cyclopeptides named squamins C–F (1–4) were iso lated. Their structures were determined using NMR spectroscopic techniques together with quantum mechanical calculations (QM-NMR) (Daranas and Sarotti, 2021), ESI-HRMS data and a modified version of Marfey’s method using LC-UV (Unno et al, 2020; Bhushan and Brück ner, 2004). The cytotoxicity bioassays undertaken indicated that these compounds possess moderate activity against the DU-145 (human prostate cancer) and HeLa (human cervical carcinoma) cell lines
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