Abstract
Method We recruited 170 patients (47 with SRA) from two University asthma clinics. Patients were submitted to pulmonary function testing, measurement of fractional exhaled nitric oxide (FeNO), and sputum induction with calculation of inflammatory cells and measurement of IL-13 in the supernatant. Asthma control test (ACT) was used for evaluation of asthma control (ACT values >19 identified well-controlled asthma). Severe refractory asthma was defined by the ATS criteria.
Highlights
The management of patients with severe refractory asthma (SRA) is a difficult task that may benefit from the use of non-invasive assessment by biomarkers
Patients were submitted to pulmonary function testing, measurement of fractional exhaled nitric oxide (FeNO), and sputum induction with calculation of inflammatory cells and measurement of IL-13 in the supernatant
IL-13 in sputum supernatant was increased in patients with SRA compared to patients with mild-to-moderate asthma [median (IQR): 156 (80-245) pg/mL vs. 78 (66103) pg/mL, p
Summary
Papaioannou, Anastasia Papaporfyriou, Georgios Hillas, Spyros Papiris, Nikolaos Koulouris, Stelios Loukides, Konstantinos Kostikas. From 2nd International Severe Asthma Forum (ISAF) Athens, Greece. From 2nd International Severe Asthma Forum (ISAF) Athens, Greece. 13-15 November 2014
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